Garlic (Allium sativum) has been used among centuries for treating various diseases, its consumption has been related to reduce cancer risk. Some garlic constituents have been shown to alter activation of carcinogens and to cause growth inhibition of tumor cells (Reddy et al., 1993). Garlic extracts and components effectively block experimentally induced tumors (Oommen et al., 2004). Allicin, the major component present in freshly crushed garlic, is formed from Garlic bulbs contain alliin. When crushed, the bulbs release the enzyme alliinase, which converts alliin to allicin (diallyl thiosulfinate) and other thiosulfinates. Allicin is one of the most biologically active compounds of garlic (Hirsch et al., 2000), it was reported to affect different biological activities such as antibacterial, antiparasite and antifungal activities. It was also shown that garlic compounds may reduce serum lipid levels, as well as inhibit platelet aggregation. Interestingly, allicin has radical scavenging properties in activated granulocytes and may also inhibit inducible nitric oxide synthase expression in activated macrophages (Lang et al., 2004). Epidemiological studies and animal experiments have suggested that several garlicderived compounds have potential anticarcinogens (Sun and Wang, 2003), inhibit the proliferation of cancer cells, and some of them cause apoptosis in tumor cells of different tissue origin (Kwon and Moon 2005; Arditti and Rabinkov 2005; Jakubikova and Sedlak 2006).
Fonte http://www.redalyc.org/pdf/856/85622430003.pdf PADILLA CAMBEROS, Eduardo; PADILLA CAMBEROS, Claudia Antitumoral activity of allicin from garlic Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas, vol. 10, núm. 5, septiembre, 2011, pp. 423-428 Universidad de Santiago de Chile Santiago, Chile
Antitumoral activity of allicin from garlic [Actividad antitumoral de alicina de ajo] Eduardo PADILLA CAMBEROS1 & Claudia PADILLA CAMBEROS2 1Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco. Avenida Normalistas 800 C.P. 44270 Guadalajara, Jalisco. México. 2 Centro Universitario de la Ciénega, Universidad de Guadalajara. México
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